Linked Life Data

10578449

Source:http://linkedlifedata.com/resource/pubmed/id/10578449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-12-29
pubmed:abstractText
Understanding the biology of the pharmacological stabilization of mood will undoubtedly serve to provide significant insight into the pathophysiology of manic-depressive illness (MDI). Accumulating evidence from our laboratories and those of other researchers has identified the family of protein kinase C isozymes as a shared target in the brain for the long-term action of both lithium and valproate. In rats chronically treated with lithium, there is a reduction in the hippocampus of the expression of two protein kinase isozymes, alpha and epsilon, as well as a reduction in the expression of a major PKC substrate, MARCKS, which has been implicated in long-term neuroplastic events in the developing and adult brain. In addition, we have been investigating the down-stream impact of these mood stabilizers on another kinase system, GSK-3 beta and on the AP-1 family of transcription factors. Further studies have generated promising preliminary data in support of the antimanic action of tamoxifen, and antiestrogen that is also a PKC inhibitor. Future studies must address the therapeutic relevance of these protein targets in the brain using innovative strategies in both animal and clinical investigations to ultimately create opportunities for the discovery of the next generations of mood stabilizers for the treatment of MDI.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-3223
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1328-51
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10578449-Animals, pubmed-meshheading:10578449-Antimanic Agents, pubmed-meshheading:10578449-Awards and Prizes, pubmed-meshheading:10578449-Binding, Competitive, pubmed-meshheading:10578449-Bipolar Disorder, pubmed-meshheading:10578449-Blotting, Western, pubmed-meshheading:10578449-Brain, pubmed-meshheading:10578449-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:10578449-Disease Models, Animal, pubmed-meshheading:10578449-Enzyme Activators, pubmed-meshheading:10578449-Glycogen Synthase Kinase 3, pubmed-meshheading:10578449-Humans, pubmed-meshheading:10578449-Lithium, pubmed-meshheading:10578449-Male, pubmed-meshheading:10578449-Protein Kinase C, pubmed-meshheading:10578449-Rats, pubmed-meshheading:10578449-Rats, Sprague-Dawley, pubmed-meshheading:10578449-Research, pubmed-meshheading:10578449-Signal Transduction, pubmed-meshheading:10578449-Transcription, Genetic, pubmed-meshheading:10578449-Transcription Factor AP-1, pubmed-meshheading:10578449-Valproic Acid
pubmed:year
1999
pubmed:articleTitle
Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness.
pubmed:affiliation
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't