|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5445
|
|
pubmed:dateCreated |
1999-12-14
|
|
pubmed:abstractText |
The hallmark of rheumatoid arthritis (RA) is specific destruction of the synovial joints. In a mouse line that spontaneously develops a disorder with many of the features of human RA, disease is initiated by T cell recognition of a ubiquitously expressed self-antigen; once initiated, pathology is driven almost entirely by immunoglobulins. In this study, the target of both the initiating T cells and pathogenic immunoglobulins was identified as glucose-6-phosphate isomerase, a glycolytic enzyme. Thus, some forms of RA or related arthritides may develop by a mechanism fundamentally different from the currently popular paradigm of a joint-specific T cell response.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
286
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1732-5
|
|
pubmed:dateRevised |
2007-3-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10576739-Animals,
pubmed-meshheading:10576739-Antigen Presentation,
pubmed-meshheading:10576739-Antigen-Antibody Complex,
pubmed-meshheading:10576739-Arthritis, Rheumatoid,
pubmed-meshheading:10576739-Autoantibodies,
pubmed-meshheading:10576739-Autoantigens,
pubmed-meshheading:10576739-B-Lymphocytes,
pubmed-meshheading:10576739-Cross Reactions,
pubmed-meshheading:10576739-Disease Models, Animal,
pubmed-meshheading:10576739-Glucose-6-Phosphate Isomerase,
pubmed-meshheading:10576739-Humans,
pubmed-meshheading:10576739-Immunoglobulins,
pubmed-meshheading:10576739-Joints,
pubmed-meshheading:10576739-Mice,
pubmed-meshheading:10576739-Mice, Inbred C57BL,
pubmed-meshheading:10576739-Mice, Inbred NOD,
pubmed-meshheading:10576739-Mice, Transgenic,
pubmed-meshheading:10576739-Recombinant Fusion Proteins,
pubmed-meshheading:10576739-T-Lymphocytes
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
|
|
pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), BP 163, 67404 Illkirch, C.U. de Strasbourg, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
