Source:http://linkedlifedata.com/resource/pubmed/id/10576696
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
1999-12-20
|
| pubmed:abstractText |
A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT1A and serotonin reuptake receptors which shows excellent pharmacokinetic parameters.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:BeerM SMS,
pubmed-author:CastroJ LJL,
pubmed-author:ChengS KSK,
pubmed-author:EvansD CDC,
pubmed-author:HealdAA,
pubmed-author:HitzelLL,
pubmed-author:HungEE,
pubmed-author:MacLeodA MAM,
pubmed-author:Mortishire-SmithRR,
pubmed-author:O'ConnorDD,
pubmed-author:WattA PAP,
pubmed-author:van NielM BMB
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3243-8
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading | |
| pubmed:year |
1999
|
| pubmed:articleTitle |
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.
|
| pubmed:affiliation |
Department of Chemistry, Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, United Kingdom. Monique_vanniel@merck.com
|
| pubmed:publicationType |
Journal Article
|