Linked Life Data

10576411

Source:http://linkedlifedata.com/resource/pubmed/id/10576411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-12-22
pubmed:abstractText
We discuss the problem of estimating the median time and comparison of survival curves when data are nonrandomly censored in analgesic trials. In these trials patients experience post-surgical pain at the time of randomization. Time to onset of analgesia is measured by patient-administered stopwatches. An effective analgesic is one for which the median time to onset is "short." The study design allows patients to remedicate if their pain persists, and this remedication prior to pain relief censors the time-to-onset measures. The time to onset for patients who remedicate is nonrandomly censored. Assuming noninformative censoring yields misleading results with the Kaplan-Meier method (for estimation of median time) and the log-rank test (for comparison of survival curves). This assumption can also obscure the superior effect of an effective analgesic over an ineffective one. We propose a simple and intuitive way to handle the nonrandomly censored data in analgesic trials in order to (a) estimate the median time to pain relief and (b) compare the survival distributions between treatments. The method proposed is applied to data collected from an acute pain clinical trial, and the results are discussed.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1054-3406
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
683-93
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A simple way to estimate the median time and compare survival distributions in analgesic trials under informative censoring.
pubmed:affiliation
Roche Pharmaceuticals, Palo Alto, California 94304, USA.
pubmed:publicationType
Journal Article, Comparative Study