Linked Life Data

10575135

Source:http://linkedlifedata.com/resource/pubmed/id/10575135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2000-1-13
pubmed:abstractText
The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (DeltaCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of DeltaCCR5 in in vitro as well as in vivo studies. We provide data that suggest that CCR5 polymorphism may affect the onset of AIDS dementia complex in vivo and data that show that HIV-1 replication is influenced by the DeltaCCR5 allele in vitro. Knowing the CCR5 genotype of an individual will help to better interpret research results and may even provide new information about mechanisms of disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0928-8244
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Potential role of CCR5 polymorphism in the development of AIDS dementia complex.
pubmed:affiliation
Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, section NeuroImmunology, AZU, room G04.614, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. l.a.boven@lab.azu.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't