Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-12-21
pubmed:abstractText
In order to analyse the prevalence and significance of cryoglobulinaemia in patients with chronic hepatitis C virus (HCV) infection and the possible relationship of cryoglobulinaemia with the genotypes of HCV, we studied 89 patients with chronic HCV infection, 42 healthy controls and 22 patients with alcoholic cirrhosis. The patients with HCV were divided into three different groups according to the presence of cirrhosis and alanine aminotransferase levels. Moreover, in 20 patients with HCV and cryoglobulinaemia, HCV RNA sequences were quantified in serum and in cryoprecipitate. Cryoglobulins were detected more frequently in patients with chronic HCV infection than in healthy controls (42.6% vs. 4.7%; P<0.0001). Cryoglobulins were present in 68.4% of patients with HCV-related cirrhosis, which was nearly twice the figure in noncirrhotic HCV-infected patients and alcoholic cirrhotic patients. There were no differences in age, sex, aminotransferase levels or HCV genotype distribution in HCV-infected patients with or without cryoglobulinaemia. Only 13% of patients with chronic HCV infection and cryoglobulins showed symptoms of cryoglobulinaemia. There was a linear association between HCV RNA concentration in sera and in cryoprecipitates (P<0.0005). Patients with chronic HCV infection had a high prevalence of cryoglobulinaemia, especially in advanced forms of the disease, but clinical findings are few. There was no relationship with the genotype of HCV. The presence of HCV RNA in cryoprecipitates supported the hypothesis on the aetiological role of HCV in mixed cryoglobulinaemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0785-3890
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
352-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10574508-Adult, pubmed-meshheading:10574508-Aged, pubmed-meshheading:10574508-Aged, 80 and over, pubmed-meshheading:10574508-Case-Control Studies, pubmed-meshheading:10574508-Comorbidity, pubmed-meshheading:10574508-Cryoglobulinemia, pubmed-meshheading:10574508-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:10574508-Female, pubmed-meshheading:10574508-Genotype, pubmed-meshheading:10574508-Hepacivirus, pubmed-meshheading:10574508-Hepatitis C, Chronic, pubmed-meshheading:10574508-Humans, pubmed-meshheading:10574508-Liver Cirrhosis, Alcoholic, pubmed-meshheading:10574508-Male, pubmed-meshheading:10574508-Middle Aged, pubmed-meshheading:10574508-Prevalence, pubmed-meshheading:10574508-RNA, Viral, pubmed-meshheading:10574508-Reference Values, pubmed-meshheading:10574508-Sensitivity and Specificity, pubmed-meshheading:10574508-Spain
pubmed:year
1999
pubmed:articleTitle
Mixed cryoglobulinaemia in patients with chronic hepatitis C infection: prevalence, significance and relationship with different viral genotypes.
pubmed:affiliation
Service of Internal Medicine, Hospital Ntra Sra de Aránzazu, Donostia-San Sebastián, Spain. jgallego@medicina.ub.es
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't