| pubmed-article:10573523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10573523 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10573523 | lifeskim:mentions | umls-concept:C0083031 | lld:lifeskim |
| pubmed-article:10573523 | lifeskim:mentions | umls-concept:C0160390 | lld:lifeskim |
| pubmed-article:10573523 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:10573523 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:10573523 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10573523 | pubmed:dateCreated | 1999-12-16 | lld:pubmed |
| pubmed-article:10573523 | pubmed:abstractText | Recombinant human interleukin-11 (rhIL-11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro-inflammatory mediators from activated macrophages. rhIL-11 also inhibits production of several immunostimulatory cytokines such as IL-12 and interferon gamma (IFN-gamma) and has shown biological activity in multiple animal models of inflammatory disease consistent with immunomodulatory effects on macrophages and T cells. To further elucidate the anti-inflammatory activity of rhIL-11 in vivo, the effect of rhIL-11 in a model of Concanavalin A (Con-A)-induced T-cell-mediated hepatotoxicity was examined. Administration of a single dose of rhIL-11 before Con-A administration reduced centrilobular liver necrosis and enhanced survival. A dose-dependent reduction in serum levels of liver enzymes, tumor necrosis factor alpha (TNF-alpha), and IFN-gamma corresponded with this amelioration of liver damage. No significant change in infiltrating lymphocyte populations in the liver was observed following rhIL-11 treatment. Taken together, these results indicate that rhIL-11 ameliorates T-cell-mediated hepatic injury and suggests its therapeutic potential to treat inflammatory liver disease. | lld:pubmed |
| pubmed-article:10573523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10573523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10573523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10573523 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10573523 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:EricksonJJ | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:BouchardPP | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:DornerA JAJ | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:DonnellyLL | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:TrepicchioW... | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:BozziEE | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:BlissJ LJL | lld:pubmed |
| pubmed-article:10573523 | pubmed:author | pubmed-author:MaylorRR | lld:pubmed |
| pubmed-article:10573523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10573523 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:10573523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10573523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10573523 | pubmed:pagination | 1441-7 | lld:pubmed |
| pubmed-article:10573523 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10573523 | pubmed:meshHeading | pubmed-meshheading:10573523... | lld:pubmed |
| pubmed-article:10573523 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10573523 | pubmed:articleTitle | Interleukin-11 reduces T-cell-dependent experimental liver injury in mice. | lld:pubmed |
| pubmed-article:10573523 | pubmed:affiliation | Department of Molecular Medicine, Genetics Institute, Andover, MA 01810, USA. | lld:pubmed |
| pubmed-article:10573523 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10573523 | lld:pubmed |
