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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
Recombinant human interleukin-11 (rhIL-11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro-inflammatory mediators from activated macrophages. rhIL-11 also inhibits production of several immunostimulatory cytokines such as IL-12 and interferon gamma (IFN-gamma) and has shown biological activity in multiple animal models of inflammatory disease consistent with immunomodulatory effects on macrophages and T cells. To further elucidate the anti-inflammatory activity of rhIL-11 in vivo, the effect of rhIL-11 in a model of Concanavalin A (Con-A)-induced T-cell-mediated hepatotoxicity was examined. Administration of a single dose of rhIL-11 before Con-A administration reduced centrilobular liver necrosis and enhanced survival. A dose-dependent reduction in serum levels of liver enzymes, tumor necrosis factor alpha (TNF-alpha), and IFN-gamma corresponded with this amelioration of liver damage. No significant change in infiltrating lymphocyte populations in the liver was observed following rhIL-11 treatment. Taken together, these results indicate that rhIL-11 ameliorates T-cell-mediated hepatic injury and suggests its therapeutic potential to treat inflammatory liver disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-9139
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1441-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10573523-Alanine Transaminase,
pubmed-meshheading:10573523-Animals,
pubmed-meshheading:10573523-Aspartate Aminotransferases,
pubmed-meshheading:10573523-Concanavalin A,
pubmed-meshheading:10573523-Dose-Response Relationship, Drug,
pubmed-meshheading:10573523-Drug-Induced Liver Injury,
pubmed-meshheading:10573523-Enzyme Induction,
pubmed-meshheading:10573523-Female,
pubmed-meshheading:10573523-Humans,
pubmed-meshheading:10573523-Interferon-gamma,
pubmed-meshheading:10573523-Interleukin-11,
pubmed-meshheading:10573523-Interleukin-2,
pubmed-meshheading:10573523-Liver,
pubmed-meshheading:10573523-Mice,
pubmed-meshheading:10573523-Mice, Inbred BALB C,
pubmed-meshheading:10573523-Necrosis,
pubmed-meshheading:10573523-Recombinant Proteins,
pubmed-meshheading:10573523-T-Lymphocytes,
pubmed-meshheading:10573523-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Interleukin-11 reduces T-cell-dependent experimental liver injury in mice.
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pubmed:affiliation |
Department of Molecular Medicine, Genetics Institute, Andover, MA 01810, USA.
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pubmed:publicationType |
Journal Article
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