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rdf:type |
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lifeskim:mentions |
umls-concept:C0021081,
umls-concept:C0028778,
umls-concept:C0035647,
umls-concept:C0039194,
umls-concept:C0040735,
umls-concept:C0076316,
umls-concept:C0086418,
umls-concept:C0229664,
umls-concept:C0243071,
umls-concept:C0301258,
umls-concept:C0441655
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pubmed:issue |
9
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pubmed:dateCreated |
1999-12-2
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pubmed:abstractText |
T lymphocyte activation mediated by CD28 costimulation plays a critical role in graft rejection. Plant alkaloid tetrandrine, purified from a Chinese antirheumatic herb, is a potent immunosuppressant. Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were readily compared with the effects of three tetrandrine analogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/dauricine,
http://linkedlifedata.com/resource/pubmed/chemical/tetrandrine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0041-1337
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1383-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10573080-Alkaloids,
pubmed-meshheading:10573080-Antigens, CD28,
pubmed-meshheading:10573080-Benzylisoquinolines,
pubmed-meshheading:10573080-Cyclosporine,
pubmed-meshheading:10573080-Cytokines,
pubmed-meshheading:10573080-Humans,
pubmed-meshheading:10573080-Immunosuppressive Agents,
pubmed-meshheading:10573080-Isoquinolines,
pubmed-meshheading:10573080-Lymphocyte Activation,
pubmed-meshheading:10573080-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:10573080-T-Lymphocytes,
pubmed-meshheading:10573080-Tetradecanoylphorbol Acetate,
pubmed-meshheading:10573080-Tetrahydroisoquinolines
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pubmed:year |
1999
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pubmed:articleTitle |
Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology.
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pubmed:affiliation |
Department of Medicine, Tri-Service General Hospital, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China. haungben@tpts5.seed.net.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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