Source:http://linkedlifedata.com/resource/pubmed/id/10572913
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2000-1-28
|
| pubmed:abstractText |
We evaluated the methodological issues underlying the assessment of normal confidence intervals, as used in clinically based region-of-interest (ROI) semi-quantification of 99Tcm-HMPAO brain SPET. At two different centres equipped with high-resolution, triple-headed gamma cameras, HMPAO SPET scans were performed on two groups of 24 and 15 healthy volunteers respectively. Together with an operator-defined analysis (ODA), a semi-automated analysis (SAA) was conducted on the normal datasets in one centre. Tests of intra- and inter-observer variability were performed. Repeat scans were performed within 72 h after the first to analyse short-term regional inter-study variations. The overall regional uptake showed significant differences in most regions between both normal datasets. Intra-observer and inter-observer reproducibility were on average within 4% for the ODA, while for the SAA it was less than 1%. Inter-study variations were excellent for both centres, ranging from -4% to +3% for most regions studied. The variability in clinical brain perfusion studies largely depends on the reproducibility of the data analysis technique. A semi-automated approach shows clear advantages over an entirely operator-defined approach. Intra-subject repeat studies show enough stability for use as reliable baseline measurements in the construction of a normal database or to allow activation studies with high sensitivity.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0143-3636
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1031-40
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10572913-Adult,
pubmed-meshheading:10572913-Aging,
pubmed-meshheading:10572913-Brain,
pubmed-meshheading:10572913-Databases, Factual,
pubmed-meshheading:10572913-Evaluation Studies as Topic,
pubmed-meshheading:10572913-Female,
pubmed-meshheading:10572913-Functional Laterality,
pubmed-meshheading:10572913-Humans,
pubmed-meshheading:10572913-Image Processing, Computer-Assisted,
pubmed-meshheading:10572913-Male,
pubmed-meshheading:10572913-Middle Aged,
pubmed-meshheading:10572913-Observer Variation,
pubmed-meshheading:10572913-Radiopharmaceuticals,
pubmed-meshheading:10572913-Reproducibility of Results,
pubmed-meshheading:10572913-Sex Characteristics,
pubmed-meshheading:10572913-Technetium Tc 99m Exametazime,
pubmed-meshheading:10572913-Tomography, Emission-Computed, Single-Photon
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Quantification of 99Tcm-HMPAO brain SPET in two series of healthy volunteers using different triple-headed SPET configurations: normal databases and methodological considerations.
|
| pubmed:affiliation |
Division of Nuclear Medicine, University Hospital, Ghent, Belgium. koen.vanlaere@rug.ac.be
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|