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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-12-15
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|
pubmed:abstractText |
Using HPLC with fluorescence detector we studied elimination kinetics of the antioxidant drug mexidol and its glucuronoconjugated metabolite in 16 patients suffering from neurosis and traumatic CNS injury after receiving mexadol (in a dose of 500 mg, in tablets). It is found that mexidol undergoes rapid glucuronoconjugation and is excreted with urine (0.31% and 49.6% of the received dose in the form of mexidol and its glucuronoconjugate, respectively) within 11.5-h period of examination. A substantial variability in the rate and degree of mexidol and glucuronoconjugate elimination with urine is observed. A trend to intensive glucuronoconjugation is observed in patients aged up to 40.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:issn |
0869-2092
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
42-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10572752-Adult,
pubmed-meshheading:10572752-Aging,
pubmed-meshheading:10572752-Antioxidants,
pubmed-meshheading:10572752-Chromatography, High Pressure Liquid,
pubmed-meshheading:10572752-Glucuronates,
pubmed-meshheading:10572752-Humans,
pubmed-meshheading:10572752-Linear Models,
pubmed-meshheading:10572752-Mental Disorders,
pubmed-meshheading:10572752-Middle Aged,
pubmed-meshheading:10572752-Picolines,
pubmed-meshheading:10572752-Psychotropic Drugs,
pubmed-meshheading:10572752-Tablets,
pubmed-meshheading:10572752-Time Factors
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pubmed:articleTitle |
[The kinetics of the urinary excretion of mexidol and its glucuronate conjugate in patients].
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pubmed:affiliation |
Institute of Pharmacology, RAS, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
English Abstract
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