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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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|
pubmed:dateCreated |
1999-12-15
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|
pubmed:abstractText |
The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.
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pubmed:language |
rus
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0869-2092
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
15-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10572744-Animals,
pubmed-meshheading:10572744-Antioxidants,
pubmed-meshheading:10572744-Brain,
pubmed-meshheading:10572744-Brain Ischemia,
pubmed-meshheading:10572744-Cats,
pubmed-meshheading:10572744-Cerebrovascular Circulation,
pubmed-meshheading:10572744-Drug Evaluation, Preclinical,
pubmed-meshheading:10572744-Female,
pubmed-meshheading:10572744-Male,
pubmed-meshheading:10572744-Picolines,
pubmed-meshheading:10572744-Pyridines,
pubmed-meshheading:10572744-Time Factors
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|
pubmed:articleTitle |
[The anti-ischemic effects of 3-hydroxypyridine derivatives in cerebrovascular pathology].
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|
pubmed:affiliation |
Department of Pharmacology, Pyatigorsk State Pharmaceutical Academy, Russia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|
