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pubmed-article:10571777pubmed:abstractTextDiabetic nephropathy is characterized by glomerular hypertrophy. We have recently shown that experimental diabetes mellitus is associated with an increase in glomerular expression of the cyclin kinase inhibitor p21WAF1/CIP1 (p21). Furthermore, in vitro glucose-induced mesangial cell hypertrophy is also associated with an up-regulated expression of p21. In this study, we tested the hypothesis that p21 mediates diabetic glomerular hypertrophy in vivo.lld:pubmed
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pubmed-article:10571777pubmed:articleTitleThe cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy.lld:pubmed
pubmed-article:10571777pubmed:affiliationDepartment of Medicine, University of Washington, School of Medicine, Seattle, Washington, USA.lld:pubmed
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