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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-12-10
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pubmed:abstractText |
Diabetic nephropathy is characterized by glomerular hypertrophy. We have recently shown that experimental diabetes mellitus is associated with an increase in glomerular expression of the cyclin kinase inhibitor p21WAF1/CIP1 (p21). Furthermore, in vitro glucose-induced mesangial cell hypertrophy is also associated with an up-regulated expression of p21. In this study, we tested the hypothesis that p21 mediates diabetic glomerular hypertrophy in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1691-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10571777-Animals,
pubmed-meshheading:10571777-Blood Glucose,
pubmed-meshheading:10571777-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:10571777-Cyclins,
pubmed-meshheading:10571777-DNA,
pubmed-meshheading:10571777-Diabetes Mellitus, Experimental,
pubmed-meshheading:10571777-Diabetic Nephropathies,
pubmed-meshheading:10571777-Hypertrophy,
pubmed-meshheading:10571777-Kidney Glomerulus,
pubmed-meshheading:10571777-Kidney Tubules,
pubmed-meshheading:10571777-Mice,
pubmed-meshheading:10571777-Mice, Knockout,
pubmed-meshheading:10571777-Proteinuria,
pubmed-meshheading:10571777-RNA, Messenger,
pubmed-meshheading:10571777-Streptozocin,
pubmed-meshheading:10571777-Transforming Growth Factor beta
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pubmed:year |
1999
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pubmed:articleTitle |
The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy.
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pubmed:affiliation |
Department of Medicine, University of Washington, School of Medicine, Seattle, Washington, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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