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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-6
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pubmed:databankReference |
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pubmed:abstractText |
We investigated the EGL-30 (Gqalpha) pathway in C. elegans by using genetic screens to identify genes that confer phenotypes similar to egl-30 mutants. One such gene, egl-8, encodes a phospholipase Cbeta that is present throughout the nervous system and near intestinal cell junctions. EGL-30 and EGL-8 appear to positively regulate synaptic transmission because reducing their function results in strong aldicarb resistance and slow locomotion rates. In contrast, GOA-1 (Goalpha) and DGK-1 (diacylglycerol kinase) appear to negatively regulate synaptic transmission, because reducing their function results in strong aldicarb hypersensitivity and hyperactive locomotion. A genetic analysis suggests that GOA-1 negatively regulates the EGL-30 pathway and that DGK-1 antagonizes the EGL-30 pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10571227-Animals,
pubmed-meshheading:10571227-Caenorhabditis elegans,
pubmed-meshheading:10571227-Diacylglycerol Kinase,
pubmed-meshheading:10571227-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:10571227-Helminth Proteins,
pubmed-meshheading:10571227-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:10571227-Intestines,
pubmed-meshheading:10571227-Isoenzymes,
pubmed-meshheading:10571227-Molecular Sequence Data,
pubmed-meshheading:10571227-Mutation,
pubmed-meshheading:10571227-Nervous System,
pubmed-meshheading:10571227-Phenotype,
pubmed-meshheading:10571227-Phospholipase C beta,
pubmed-meshheading:10571227-Synaptic Transmission,
pubmed-meshheading:10571227-Type C Phospholipases
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pubmed:year |
1999
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pubmed:articleTitle |
Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.
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pubmed:affiliation |
Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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