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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1999-12-23
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pubmed:abstractText |
A series of novel arylpiperidines (4a-d) which have highly potent blocking effects for both neuronal Na+ and T-type Ca2+ channels with extremely low affinity for dopamine D2 receptors were synthesized. Among these compounds, 1-(2-hydroxy-3-phenoxy)propyl-4-(4-phenoxyphenyl)-piperidine hydrochloride (4c; SUN N5030) exhibited remarkable neuroprotective activity in a transient middle cerebral artery occlusion (MCAO) model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2999-3002
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10571163-Animals,
pubmed-meshheading:10571163-Anticonvulsants,
pubmed-meshheading:10571163-Calcium Channel Blockers,
pubmed-meshheading:10571163-Calcium Channels, T-Type,
pubmed-meshheading:10571163-Epilepsy, Reflex,
pubmed-meshheading:10571163-Ischemic Attack, Transient,
pubmed-meshheading:10571163-Mice,
pubmed-meshheading:10571163-Mice, Inbred DBA,
pubmed-meshheading:10571163-Neuroprotective Agents,
pubmed-meshheading:10571163-Phenyl Ethers,
pubmed-meshheading:10571163-Piperidines,
pubmed-meshheading:10571163-Sodium Channel Blockers
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pubmed:year |
1999
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pubmed:articleTitle |
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects.
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pubmed:affiliation |
Suntory Institute for Biomedical Research, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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