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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1999-12-23
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pubmed:abstractText |
Original spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives were synthesised and led to the identification of 3e which showed good affinities for both the AMPA and the NMDA glycine-site receptors, and displayed good anticonvulsant effects after i.p. and i.v. administrations in the electroshock-induced convulsion assay in mice. The corresponding dextrorotatory isomer (+)-3e was notably more potent than the levorotatory isomer (-)-3e in in vitro and in vivo assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BoireauAA,
pubmed-author:ChevéMM,
pubmed-author:DamourDD,
pubmed-author:Genevois-BorellaAA,
pubmed-author:ImperatoAA,
pubmed-author:JimonetPP,
pubmed-author:MignaniSS,
pubmed-author:PrattJJ,
pubmed-author:RandleJ CJC,
pubmed-author:RibeillYY,
pubmed-author:StutzmannJ MJM
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2921-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10571148-Animals,
pubmed-meshheading:10571148-Binding Sites,
pubmed-meshheading:10571148-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10571148-Glycine,
pubmed-meshheading:10571148-Mice,
pubmed-meshheading:10571148-Pyrazines,
pubmed-meshheading:10571148-Receptors, AMPA,
pubmed-meshheading:10571148-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10571148-Spiro Compounds,
pubmed-meshheading:10571148-Structure-Activity Relationship
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pubmed:year |
1999
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pubmed:articleTitle |
Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo.
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pubmed:affiliation |
Rhône-Poulenc S.A., Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, Vitry-sur-Seine, France.
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pubmed:publicationType |
Journal Article
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