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pubmed-article:10570427pubmed:abstractTextE2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression from G(1) to S-phase. Somewhat paradoxically, E2F-1 also has the properties of a tumor suppressor. Overexpression of E2F-1 has been shown to induce apoptosis in some cancer cells. In the current study, the effect of adenovirus-mediated E2F-1 gene transfer on human melanoma cell growth was investigated.lld:pubmed
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pubmed-article:10570427pubmed:copyrightInfoCopyright 1999 American Cancer Society.lld:pubmed
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pubmed-article:10570427pubmed:articleTitleAdenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.lld:pubmed
pubmed-article:10570427pubmed:affiliationDepartment of Surgery, University of Louisville, James Graham Brown Cancer Center, Louisville, Kentucky, USA.lld:pubmed
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