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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-1-4
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pubmed:abstractText |
E2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression from G(1) to S-phase. Somewhat paradoxically, E2F-1 also has the properties of a tumor suppressor. Overexpression of E2F-1 has been shown to induce apoptosis in some cancer cells. In the current study, the effect of adenovirus-mediated E2F-1 gene transfer on human melanoma cell growth was investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2021-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10570427-Adenovirus E2 Proteins,
pubmed-meshheading:10570427-Apoptosis,
pubmed-meshheading:10570427-Cell Cycle,
pubmed-meshheading:10570427-Cell Division,
pubmed-meshheading:10570427-Down-Regulation,
pubmed-meshheading:10570427-Gene Transfer Techniques,
pubmed-meshheading:10570427-Genetic Vectors,
pubmed-meshheading:10570427-Humans,
pubmed-meshheading:10570427-Melanoma,
pubmed-meshheading:10570427-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10570427-Transduction, Genetic,
pubmed-meshheading:10570427-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.
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pubmed:affiliation |
Department of Surgery, University of Louisville, James Graham Brown Cancer Center, Louisville, Kentucky, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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