| pubmed-article:10570304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0065067 | lld:lifeskim |
| pubmed-article:10570304 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10570304 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10570304 | pubmed:dateCreated | 1999-12-20 | lld:pubmed |
| pubmed-article:10570304 | pubmed:abstractText | Cell adhesion molecule expression (CAM) and IL-8 release in lung microvascular endothelium facilitate neutrophil accumulation in the lung. This study investigated the effects of lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria, alone and with LPS or TNF-alpha, on CAM expression and IL-8 release in human lung microvascular endothelial cells (HLMVEC). The concentration-dependent effects of Staphylococcus aureus (S. aureus) LTA (0.3-30 microg/ml) on ICAM-1 and E-selectin expression and IL-8 release were bell shaped. Streptococcus pyogenes (S. pyogenes) LTA had no effect on CAM expression, but caused a concentration-dependent increase in IL-8 release. S. aureus and S. pyogenes LTA (30 microg/ml) abolished LPS-induced CAM expression, and S. aureus LTA reduced LPS-induced IL-8 release. In contrast, the effects of S. aureus LTA with TNF-alpha on CAM expression and IL-8 release were additive. Inhibitory effects of LTA were not due to decreased HLMVEC viability, as assessed by ethidium homodimer-1 uptake. Changes in neutrophil adhesion to HLMVEC paralleled changes in CAM expression. Using RT-PCR to assess mRNA levels, S. aureus LTA (3 microg/ml) caused a protein synthesis-dependent reduction (75%) in LPS-induced IL-8 mRNA and decreased the IL-8 mRNA half-life from >6 h with LPS to approximately 2 h. These results suggest that mechanisms exist to prevent excessive endothelial cell activation in the presence of high concentrations of bacterial products. However, inhibition of HLMVEC CAM expression and IL-8 release ultimately may contribute to decreased neutrophil accumulation, persistence of bacteria in the lung, and increased severity of infection. | lld:pubmed |
| pubmed-article:10570304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10570304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570304 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10570304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10570304 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10570304 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10570304 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:10570304 | pubmed:author | pubmed-author:HellewellP... | lld:pubmed |
| pubmed-article:10570304 | pubmed:author | pubmed-author:Burke-Gaffney... | lld:pubmed |
| pubmed-article:10570304 | pubmed:author | pubmed-author:BleaseKK | lld:pubmed |
| pubmed-article:10570304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10570304 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10570304 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10570304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10570304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10570304 | pubmed:pagination | 6139-47 | lld:pubmed |
| pubmed-article:10570304 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10570304 | pubmed:meshHeading | pubmed-meshheading:10570304... | lld:pubmed |
| pubmed-article:10570304 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10570304 | pubmed:articleTitle | Lipoteichoic acid inhibits lipopolysaccharide-induced adhesion molecule expression and IL-8 release in human lung microvascular endothelial cells. | lld:pubmed |
| pubmed-article:10570304 | pubmed:affiliation | Applied Pharmacology and Unit of Critical Care, National Heart and Lung Institute Division, Imperial College School of Medicine, London, United Kingdom. | lld:pubmed |
| pubmed-article:10570304 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10570304 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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