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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5444
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pubmed:dateCreated |
1999-12-9
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pubmed:abstractText |
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabinose,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/C18G peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitates,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/PhoP protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/PhoQ protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Polymyxins,
http://linkedlifedata.com/resource/pubmed/chemical/aminoarabinose
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1561-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10567263-Acylation,
pubmed-meshheading:10567263-Arabinose,
pubmed-meshheading:10567263-Bacterial Proteins,
pubmed-meshheading:10567263-Cells, Cultured,
pubmed-meshheading:10567263-Cystic Fibrosis,
pubmed-meshheading:10567263-Drug Resistance, Microbial,
pubmed-meshheading:10567263-Humans,
pubmed-meshheading:10567263-Infant,
pubmed-meshheading:10567263-Interleukin-8,
pubmed-meshheading:10567263-Lipid A,
pubmed-meshheading:10567263-Lipopolysaccharides,
pubmed-meshheading:10567263-Magnesium,
pubmed-meshheading:10567263-Mutation,
pubmed-meshheading:10567263-Palmitates,
pubmed-meshheading:10567263-Peptides,
pubmed-meshheading:10567263-Polymyxins,
pubmed-meshheading:10567263-Pseudomonas Infections,
pubmed-meshheading:10567263-Pseudomonas aeruginosa,
pubmed-meshheading:10567263-Respiratory System,
pubmed-meshheading:10567263-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:10567263-Virulence
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pubmed:year |
1999
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pubmed:articleTitle |
Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.
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pubmed:affiliation |
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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