| pubmed-article:10566678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0812260 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0238463 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0694890 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C1709815 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0543431 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C1512456 | lld:lifeskim |
| pubmed-article:10566678 | lifeskim:mentions | umls-concept:C0442821 | lld:lifeskim |
| pubmed-article:10566678 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10566678 | pubmed:dateCreated | 1999-11-26 | lld:pubmed |
| pubmed-article:10566678 | pubmed:abstractText | A sharp increase in the incidence of pediatric thyroid papillary cancer was documented after the Chernobyl power plant explosion. An increased prevalence of rearrangements of the RET protooncogene (RET/PTC rearrangements) has been reported in Belarussian post-Chernobyl papillary carcinomas arising between 1990 and 1995. We analyzed 67 post-Chernobyl pediatric papillary carcinomas arising in 1995-1997 for RET/PTC activation: 28 were from Ukraine and 39 were from Belarus. The study, conducted by a combined immunohistochemistry and RT-PCR approach, demonstrated a high frequency (60.7% of the Ukrainian and 51.3% of the Belarussian cases) of RET/PTC activation. A strong correlation was observed between the solid-follicular subtype of papillary carcinoma and the RET/PTC3 isoform: 19 of the 24 RET/PTC-positive solid-follicular carcinomas harbored a RET/PTC3 rearrangement, whereas only 5 had a RET/PTC1 rearrangement. Taken together these results support the concept that RET/PTC activation plays a central role in the pathogenesis of thyroid papillary carcinomas in both Ukraine and Belarus after the Chernobyl accident. | lld:pubmed |
| pubmed-article:10566678 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10566678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10566678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10566678 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10566678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10566678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10566678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10566678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10566678 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10566678 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:BogdanovaT... | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:FuscoAA | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:WilliamsE DED | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:VecchioGG | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:CookH AHA | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:CherstvoyE... | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:SalvatoreGG | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:SantoroMM | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:ChiappettaGG | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:ThomasG AGA | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:TronkoN DND | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:VigliettoGG | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:BunnellHH | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:PentimalliFF | lld:pubmed |
| pubmed-article:10566678 | pubmed:author | pubmed-author:NerovnyaAA | lld:pubmed |
| pubmed-article:10566678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10566678 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:10566678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10566678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10566678 | pubmed:pagination | 4232-8 | lld:pubmed |
| pubmed-article:10566678 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10566678 | pubmed:meshHeading | pubmed-meshheading:10566678... | lld:pubmed |
| pubmed-article:10566678 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10566678 | pubmed:articleTitle | High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. | lld:pubmed |
| pubmed-article:10566678 | pubmed:affiliation | Thyroid Carcinogenesis Group, University of Cambridge, Strangeways Research Laboratory, United Kingdom. | lld:pubmed |
| pubmed-article:10566678 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10566678 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10566678 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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