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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-11-26
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pubmed:abstractText |
A sharp increase in the incidence of pediatric thyroid papillary cancer was documented after the Chernobyl power plant explosion. An increased prevalence of rearrangements of the RET protooncogene (RET/PTC rearrangements) has been reported in Belarussian post-Chernobyl papillary carcinomas arising between 1990 and 1995. We analyzed 67 post-Chernobyl pediatric papillary carcinomas arising in 1995-1997 for RET/PTC activation: 28 were from Ukraine and 39 were from Belarus. The study, conducted by a combined immunohistochemistry and RT-PCR approach, demonstrated a high frequency (60.7% of the Ukrainian and 51.3% of the Belarussian cases) of RET/PTC activation. A strong correlation was observed between the solid-follicular subtype of papillary carcinoma and the RET/PTC3 isoform: 19 of the 24 RET/PTC-positive solid-follicular carcinomas harbored a RET/PTC3 rearrangement, whereas only 5 had a RET/PTC1 rearrangement. Taken together these results support the concept that RET/PTC activation plays a central role in the pathogenesis of thyroid papillary carcinomas in both Ukraine and Belarus after the Chernobyl accident.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-972X
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pubmed:author |
pubmed-author:BogdanovaT ITI,
pubmed-author:BunnellHH,
pubmed-author:CherstvoyE DED,
pubmed-author:ChiappettaGG,
pubmed-author:CookH AHA,
pubmed-author:FuscoAA,
pubmed-author:NerovnyaAA,
pubmed-author:PentimalliFF,
pubmed-author:SalvatoreGG,
pubmed-author:SantoroMM,
pubmed-author:ThomasG AGA,
pubmed-author:TronkoN DND,
pubmed-author:VecchioGG,
pubmed-author:VigliettoGG,
pubmed-author:WilliamsE DED
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4232-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10566678-Adolescent,
pubmed-meshheading:10566678-Carcinoma, Papillary,
pubmed-meshheading:10566678-Child,
pubmed-meshheading:10566678-Drosophila Proteins,
pubmed-meshheading:10566678-Female,
pubmed-meshheading:10566678-Gene Rearrangement,
pubmed-meshheading:10566678-Humans,
pubmed-meshheading:10566678-Male,
pubmed-meshheading:10566678-Power Plants,
pubmed-meshheading:10566678-Proto-Oncogene Proteins,
pubmed-meshheading:10566678-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:10566678-Radioactive Hazard Release,
pubmed-meshheading:10566678-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10566678-Republic of Belarus,
pubmed-meshheading:10566678-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10566678-Thyroid Neoplasms,
pubmed-meshheading:10566678-Ukraine
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pubmed:year |
1999
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pubmed:articleTitle |
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
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pubmed:affiliation |
Thyroid Carcinogenesis Group, University of Cambridge, Strangeways Research Laboratory, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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