Source:http://linkedlifedata.com/resource/pubmed/id/10566663
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
1999-11-26
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| pubmed:abstractText |
To further define the nonhuman primate as a model of the adult human skeleton, we explored the impact of growth, natural menopause, and osteoarthritis on bone mass, serum markers of bone turnover (osteocalcin and C-terminal telopeptide of type I collagen) and measures of skeletal relevance (PTH, 25-hydroxyvitamin D, total alkaline phosphatase, calcium, phosphorus, creatinine, and albumin). Fifty-eight female (aged 4-30 yr) rhesus macaques were defined as growing (G; n = 12; < or = 10 yr old), adult premenopausal (APre; n = 30; > 10 yr old; eumenorrheic, high serum estradiol and low FSH), or postmenopausal (Post; n = 16; amenorrheic for at least 1 yr, with low serum estradiol and high FSH). Total body and posterior-anterior spinal bone masses were lower in G than APre animals (P < 0.05). Post females had lower total body, distal radius, and spinal bone mass than premenopausal animals (P < 0.05). Osteocalcin was higher in Post than APre animals (P < 0.01). Other measures showed no relationship with menopausal status. In older monkeys, spinal osteoarthritis became common, causing increased dual-energy x-ray absorptiometry-measured bone mass in the lumbar spinal posterior-anterior projection. In conclusion, after natural menopause, rhesus monkeys have lower bone mass and higher skeletal turnover without alteration of the calcium-vitamin D axis. As such, they are an excellent model of human estrogen-depletion bone loss.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcifediol,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/collagen type I trimeric...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
84
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4144-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10566663-Absorptiometry, Photon,
pubmed-meshheading:10566663-Aging,
pubmed-meshheading:10566663-Animals,
pubmed-meshheading:10566663-Body Weight,
pubmed-meshheading:10566663-Bone Density,
pubmed-meshheading:10566663-Bone Remodeling,
pubmed-meshheading:10566663-Bone and Bones,
pubmed-meshheading:10566663-Calcifediol,
pubmed-meshheading:10566663-Collagen,
pubmed-meshheading:10566663-Collagen Type I,
pubmed-meshheading:10566663-Estradiol,
pubmed-meshheading:10566663-Female,
pubmed-meshheading:10566663-Follicle Stimulating Hormone,
pubmed-meshheading:10566663-Macaca mulatta,
pubmed-meshheading:10566663-Menopause,
pubmed-meshheading:10566663-Osteoarthritis,
pubmed-meshheading:10566663-Osteocalcin,
pubmed-meshheading:10566663-Parathyroid Hormone,
pubmed-meshheading:10566663-Peptides
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| pubmed:year |
1999
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| pubmed:articleTitle |
Skeletal effects of aging and menopausal status in female rhesus macaques.
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| pubmed:affiliation |
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715-1299, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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