Linked Life Data

10566652

Source:http://linkedlifedata.com/resource/pubmed/id/10566652

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1999-11-26
pubmed:abstractText
The newly described uncoupling proteins, UCP2 and UCP3, may play a role in regulating energy expenditure (EE) in humans. GH deficiency (GHD) is associated with decreased lean body mass, increased adiposity, and reduced EE, which are reversed by GH treatment. In the present study we investigated whether GH treatment for 4 months influenced the expression of UCPs in skeletal muscle and adipose tissue in 22 GHD patients who were investigated before and after GH (n = 11) or placebo (n = 11) treatment. GH treatment increased the amount of lean body mass by 4.5% (P < 0.05) and decreased body fat mass by 12% (P < 0.05), whereas no changes in these parameters were observed after placebo treatment. The level of UCP3 messenger ribonucleic acid (mRNA) increased 3-fold (P < 0.005) in skeletal muscle and almost 2-fold (P < 0.05) in adipose tissue after GH treatment, with no changes observed after placebo treatment. Skeletal muscle UCP2 mRNA was slightly (25%), but significantly (P < 0.05), decreased, whereas the level of UCP2 mRNA in adipose tissue was unaffected after GH treatment. The T4 level was positively correlated with skeletal muscle UCP2 and UCP3 expression (r = 0.518; P < 0.05 and r = 0.463; P < 0.05, respectively). Furthermore, plasma free fatty acids were positively correlated with the expression of UCP2 (r = 0.573; P < 0.01) and UCP3 (r = 0.518; P < 0.05) in skeletal muscle. The marked increase in UCP3 expression after GH treatment indicates that the UCPs might play a role in the effects of GH on EE in GHD patients. Finally, the strong association between thyroid hormone and skeletal muscle UCP and the correlation between plasma free fatty acids and UCP expression in skeletal muscle indicate that these hormones/metabolites might influence UCP expression in humans as previously demonstrated in rodents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4073-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10566652-Adipose Tissue, pubmed-meshheading:10566652-Adult, pubmed-meshheading:10566652-Body Composition, pubmed-meshheading:10566652-Carrier Proteins, pubmed-meshheading:10566652-Energy Metabolism, pubmed-meshheading:10566652-Fatty Acids, Nonesterified, pubmed-meshheading:10566652-Female, pubmed-meshheading:10566652-Gene Expression Regulation, pubmed-meshheading:10566652-Human Growth Hormone, pubmed-meshheading:10566652-Humans, pubmed-meshheading:10566652-Ion Channels, pubmed-meshheading:10566652-Male, pubmed-meshheading:10566652-Membrane Transport Proteins, pubmed-meshheading:10566652-Mitochondrial Proteins, pubmed-meshheading:10566652-Muscle, Skeletal, pubmed-meshheading:10566652-Proteins, pubmed-meshheading:10566652-RNA, Messenger, pubmed-meshheading:10566652-Regression Analysis
pubmed:year
1999
pubmed:articleTitle
Regulation of uncoupling protein-2 and -3 by growth hormone in skeletal muscle and adipose tissue in growth hormone-deficient adults.
pubmed:affiliation
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Amtssygehus, Denmark. amtssp@aau.dk
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't