| pubmed-article:10564087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10564087 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10564087 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10564087 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:10564087 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10564087 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:10564087 | pubmed:dateCreated | 1999-12-14 | lld:pubmed |
| pubmed-article:10564087 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:abstractText | ClC-4 gene was isolated as a putative Cl(-) channel. Due to a lack of functional expression of ClC-4, its physiological role remains unknown. We isolated a human ClC-4 clone (hClC-4sk) from human skeletal muscles and stably transfected it to Chinese hamster ovary cells. Whole cell patch-clamp studies showed that the hClC-4sk channel was activated by external acidic pH and inhibited by DIDS. It passed a strong outward Cl(-) current with a permeability sequence of I(-) > Cl(-) > F(-). The hClC-4sk has consensus sites for phosphorylation by protein kinase A (PKA); however, stimulation of PKA had no effect on the currents. hClC-4sk mRNA was expressed in excitable tissues, such as heart, brain, and skeletal muscle. These functional characteristics of hClC-4sk provide a clue to its physiological role in excitable cells. | lld:pubmed |
| pubmed-article:10564087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10564087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10564087 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10564087 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:YamauchiKK | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:SasakiSS | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:SakamotoHH | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:MarumoFF | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:FukumaTT | lld:pubmed |
| pubmed-article:10564087 | pubmed:author | pubmed-author:KawasakiMM | lld:pubmed |
| pubmed-article:10564087 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10564087 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:10564087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10564087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10564087 | pubmed:pagination | C948-54 | lld:pubmed |
| pubmed-article:10564087 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10564087 | pubmed:meshHeading | pubmed-meshheading:10564087... | lld:pubmed |
| pubmed-article:10564087 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10564087 | pubmed:articleTitle | Identification of an acid-activated Cl(-) channel from human skeletal muscles. | lld:pubmed |
| pubmed-article:10564087 | pubmed:affiliation | Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. | lld:pubmed |
| pubmed-article:10564087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10564087 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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