Linked Life Data

10561758

Source:http://linkedlifedata.com/resource/pubmed/id/10561758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-11-30
pubmed:abstractText
The aim of this study was to find out lead interaction on acetylcholine-induced ileal (0.8 "to 1" longitudinal total strips) contractions in varying calcium (Ca++) or magnesium (Mg++) media and the cholinergic mechanism. Potentiation of ileal strips by lead (Pb++) remained dose-dependent as elicited by acetylcholine-induced contractions (1.81 x 10(-6) M to 1.28 x 10(-4) M). These were completely antagonized by atropine (1.01 x 10(-8) M). Lead (1.2 x 10(-5) M) potentiated contractions caused by acetylcholine in normal or in excess Ca++ media, but in low Ca++ or with various Mg++ media, lead failed to potentiate such contractions. Thus Pb++ has indirect cholinomimetic effect which involved extracellular Ca++.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-4602
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
488-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Potentiation of acetylcholine-induced smooth muscle contraction in rat ileum by lead.
pubmed:affiliation
Department of Neurobehavioural Toxicology, National Institute of Occupational Health, Gujarat, India.
pubmed:publicationType
Journal Article, In Vitro