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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-12-14
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pubmed:abstractText |
Dystrophin, the product of the gene mutated in Duchenne muscular dystrophy (DMD) is bound by its C-terminus to a protein complex including the related protein dystrobrevin. Both proteins contain a putative coiled-coil domain consisting of two alpha-helices. It has been reported that the two proteins bind to each other by the first one of the two alpha-helices. We have revisited this question using the Caenorhabditis elegans homologs of dystrophin and dystrobrevin. In vitro interaction occurs through the more conserved second helix. We propose a new model of dystrophin interactions with associated proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DTNA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dystrophin,
http://linkedlifedata.com/resource/pubmed/chemical/Dystrophin-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/syntrophin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
461
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10561496-Amino Acid Sequence,
pubmed-meshheading:10561496-Animals,
pubmed-meshheading:10561496-Caenorhabditis elegans,
pubmed-meshheading:10561496-Caenorhabditis elegans Proteins,
pubmed-meshheading:10561496-Dystrophin,
pubmed-meshheading:10561496-Dystrophin-Associated Proteins,
pubmed-meshheading:10561496-Glutathione Transferase,
pubmed-meshheading:10561496-Humans,
pubmed-meshheading:10561496-Membrane Proteins,
pubmed-meshheading:10561496-Models, Biological,
pubmed-meshheading:10561496-Molecular Sequence Data,
pubmed-meshheading:10561496-Muscle Proteins,
pubmed-meshheading:10561496-Nerve Tissue Proteins,
pubmed-meshheading:10561496-Neuropeptides,
pubmed-meshheading:10561496-Protein Binding,
pubmed-meshheading:10561496-Protein Conformation,
pubmed-meshheading:10561496-Recombinant Fusion Proteins,
pubmed-meshheading:10561496-Sequence Homology, Amino Acid
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pubmed:year |
1999
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pubmed:articleTitle |
In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin.
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pubmed:affiliation |
IMPC, CNRS-UPR411, 660 route des lucioles, 06560, Sophia Antipolis, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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