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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-1-13
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pubmed:abstractText |
The mechanisms that cause chemoresistance in non-small-cell lung cancer (NSCLC) patients have yet to be clearly elucidated. Paclitaxel is a tubulin-disrupting agent that binds preferentially to beta-tubulin. Tubulins are guanosine triphosphate (GTP)-binding proteins. Beta-tubulin is a GTPase, whereas alpha-tubulin has no enzyme activity. We reasoned that polymerase chain reaction (PCR) and DNA sequencing of the beta-tubulin gene could reveal more information regarding the connection between beta-tubulin mutations and primary paclitaxel resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:AlberolaVV,
pubmed-author:González-LarribaJ LJL,
pubmed-author:LeeJ SJS,
pubmed-author:LoJ SJS,
pubmed-author:LorenzoJ CJC,
pubmed-author:MartínCC,
pubmed-author:MonzóMM,
pubmed-author:NúñezLL,
pubmed-author:O'BrateAA,
pubmed-author:RosellRR,
pubmed-author:SánchezJ JJJ
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1786-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10561216-Adult,
pubmed-meshheading:10561216-Aged,
pubmed-meshheading:10561216-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10561216-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:10561216-DNA Mutational Analysis,
pubmed-meshheading:10561216-Drug Resistance, Neoplasm,
pubmed-meshheading:10561216-Female,
pubmed-meshheading:10561216-Humans,
pubmed-meshheading:10561216-Lung Neoplasms,
pubmed-meshheading:10561216-Male,
pubmed-meshheading:10561216-Middle Aged,
pubmed-meshheading:10561216-Mutation,
pubmed-meshheading:10561216-Paclitaxel,
pubmed-meshheading:10561216-Polymerase Chain Reaction,
pubmed-meshheading:10561216-Predictive Value of Tests,
pubmed-meshheading:10561216-Survival Rate,
pubmed-meshheading:10561216-Tubulin
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pubmed:year |
1999
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pubmed:articleTitle |
Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations.
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pubmed:affiliation |
Department of Pathology and the Laboratory of Molecular Biology of Cancer, Medical Oncology Service, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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