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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-1-7
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pubmed:abstractText |
The successful treatment of Hodgkin's disease has been associated with an increased incidence of secondary malignancies. To investigate whether genetic factors contribute to the development of secondary tumors, we collected family cancer histories and performed mutational analysis of the ataxia-telangiectasia (AT) gene, ATM, in a cohort of Hodgkin's disease survivors with secondary malignancies. ATM was chosen for evaluation because of the increased radiosensitivity of cells derived from AT patients and obligate heterozygotes and the epidemiologic observation that AT carriers are at increased risk for radiation-induced breast cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:BellD WDW,
pubmed-author:ChangGG,
pubmed-author:DillerLL,
pubmed-author:HaberD ADA,
pubmed-author:HegdeSS,
pubmed-author:IshiokaCC,
pubmed-author:LevittMM,
pubmed-author:MauchPP,
pubmed-author:NeubergDD,
pubmed-author:NicholsK EKE,
pubmed-author:ShafmanTT,
pubmed-author:ShannonK EKE,
pubmed-author:TarbellN JNJ,
pubmed-author:WahrerD CDC
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1259
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10561187-Adolescent,
pubmed-meshheading:10561187-Adult,
pubmed-meshheading:10561187-Aged,
pubmed-meshheading:10561187-Ataxia Telangiectasia,
pubmed-meshheading:10561187-Cohort Studies,
pubmed-meshheading:10561187-Combined Modality Therapy,
pubmed-meshheading:10561187-Female,
pubmed-meshheading:10561187-Genetic Diseases, Inborn,
pubmed-meshheading:10561187-Germ-Line Mutation,
pubmed-meshheading:10561187-Hodgkin Disease,
pubmed-meshheading:10561187-Humans,
pubmed-meshheading:10561187-Male,
pubmed-meshheading:10561187-Middle Aged,
pubmed-meshheading:10561187-Neoplasms, Radiation-Induced,
pubmed-meshheading:10561187-Neoplasms, Second Primary,
pubmed-meshheading:10561187-RNA, Messenger,
pubmed-meshheading:10561187-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
1999
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pubmed:articleTitle |
Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease.
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pubmed:affiliation |
Center for Cancer Risk Analysis, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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