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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1999-12-9
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pubmed:abstractText |
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3143-6
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pubmed:dateRevised |
2010-1-26
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pubmed:meshHeading |
pubmed-meshheading:10560741-Animals,
pubmed-meshheading:10560741-Binding, Competitive,
pubmed-meshheading:10560741-Cattle,
pubmed-meshheading:10560741-Dopamine Antagonists,
pubmed-meshheading:10560741-Drug Design,
pubmed-meshheading:10560741-Humans,
pubmed-meshheading:10560741-Ligands,
pubmed-meshheading:10560741-Molecular Structure,
pubmed-meshheading:10560741-Protein Binding,
pubmed-meshheading:10560741-Pyrroles,
pubmed-meshheading:10560741-Receptors, Dopamine D2,
pubmed-meshheading:10560741-Receptors, Dopamine D4,
pubmed-meshheading:10560741-Spiperone
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pubmed:year |
1999
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pubmed:articleTitle |
Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.
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pubmed:affiliation |
Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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