| pubmed-article:10559883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C1159709 | lld:lifeskim |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C0699759 | lld:lifeskim |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:10559883 | lifeskim:mentions | umls-concept:C0053738 | lld:lifeskim |
| pubmed-article:10559883 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10559883 | pubmed:dateCreated | 1999-12-16 | lld:pubmed |
| pubmed-article:10559883 | pubmed:abstractText | The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann-Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC. | lld:pubmed |
| pubmed-article:10559883 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10559883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10559883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10559883 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10559883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10559883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10559883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10559883 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10559883 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:KobayashiTT | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:PalmiterR DRD | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:SakurabaHH | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:GruenbergJJ | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:LindsayMM | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:PartonR GRG | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:FriasSS | lld:pubmed |
| pubmed-article:10559883 | pubmed:author | pubmed-author:BeuchatM HMH | lld:pubmed |
| pubmed-article:10559883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10559883 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:10559883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10559883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10559883 | pubmed:pagination | 113-8 | lld:pubmed |
| pubmed-article:10559883 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10559883 | pubmed:meshHeading | pubmed-meshheading:10559883... | lld:pubmed |
| pubmed-article:10559883 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10559883 | pubmed:articleTitle | Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. | lld:pubmed |
| pubmed-article:10559883 | pubmed:affiliation | Department of Biochemistry, University of Geneva, Switzerland. | lld:pubmed |
| pubmed-article:10559883 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10559883 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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