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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann-Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10559883-Animals,
pubmed-meshheading:10559883-Antiphospholipid Syndrome,
pubmed-meshheading:10559883-Cell Line,
pubmed-meshheading:10559883-Cells, Cultured,
pubmed-meshheading:10559883-Cholesterol,
pubmed-meshheading:10559883-Cricetinae,
pubmed-meshheading:10559883-Endocytosis,
pubmed-meshheading:10559883-Endosomes,
pubmed-meshheading:10559883-Fibroblasts,
pubmed-meshheading:10559883-Humans,
pubmed-meshheading:10559883-Intracellular Membranes,
pubmed-meshheading:10559883-Lysophospholipids,
pubmed-meshheading:10559883-Lysosomes,
pubmed-meshheading:10559883-Membrane Lipids,
pubmed-meshheading:10559883-Monoglycerides,
pubmed-meshheading:10559883-Niemann-Pick Diseases,
pubmed-meshheading:10559883-Receptor, IGF Type 2,
pubmed-meshheading:10559883-Recombinant Proteins,
pubmed-meshheading:10559883-Skin,
pubmed-meshheading:10559883-Zinc
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pubmed:year |
1999
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pubmed:articleTitle |
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.
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pubmed:affiliation |
Department of Biochemistry, University of Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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