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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1999-11-30
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pubmed:abstractText |
Stimulation of 5-HT(4) receptors increases atrial chronotropic and inotropic responses. Whether other electrophysiological effects are produced is unknown. In humans and swine, 5-HT(4) receptors are present only in atrium. Therefore, the effects of a novel 5-HT(4) receptor antagonist, RS-100302, and the partial agonist cisapride on atrial flutter and fibrillation induced in swine were studied to delineate the role of the 5-HT(4) receptor in modulating atrial electrophysiological properties and the antiarrhythmic potential of RS-100302.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2010-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10556228-Animals,
pubmed-meshheading:10556228-Anti-Arrhythmia Agents,
pubmed-meshheading:10556228-Atrial Fibrillation,
pubmed-meshheading:10556228-Atrial Flutter,
pubmed-meshheading:10556228-Cisapride,
pubmed-meshheading:10556228-Electrocardiography,
pubmed-meshheading:10556228-Receptors, Serotonin,
pubmed-meshheading:10556228-Receptors, Serotonin, 5-HT4,
pubmed-meshheading:10556228-Refractory Period, Electrophysiological,
pubmed-meshheading:10556228-Serotonin Antagonists,
pubmed-meshheading:10556228-Swine
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pubmed:year |
1999
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pubmed:articleTitle |
Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation.
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pubmed:affiliation |
Cardiac Electrophysiology Program, Division of Cardiology, Department of Medicine, University of California, San Diego, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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