Linked Life Data

10554587

Source:http://linkedlifedata.com/resource/pubmed/id/10554587

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-12-13
pubmed:abstractText
Detecting deviant, and potentially meaningful, auditory events depends on transient representations of preceding stimuli. Here, we examined whether the neural circuitry underlying deviance detection system varied as a function of deviance type. In different blocks of trials, participants were presented with a sequence that included standard and deviant tones differing in frequency or a sequence of tones that alternated regularly in frequency with occasional deviant repetitions. Both frequency- and pattern-deviant stimuli elicited a mismatch negativity (MMN) peaking between 120 and 175 ms poststimulus. The MMN amplitude distribution was more frontal for frequency-deviant than for pattern-deviant stimuli. There are two possible explanations for these results. Both frequency- and pattern-deviation MMNs might arise in the same set of generators whose relative strength of activation varies. Alternatively, frequency- and pattern-deviation MMNs could originate in different generators. These alternatives were investigated using principal component analysis and signal identification methods. These methods revealed that no common signal space could account for both of the MMNs, indicating different generator sources for the analysis of frequency and pattern deviance. The results suggest separate memory-related processing for auditory frequency and patterns and indicate that the neural circuit of deviance detection varies as a function of the perceptual context.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0048-5772
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
737-44
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Separate memory-related processing for auditory frequency and patterns.
pubmed:affiliation
Rotman Research Institute, Baycrest Centre for Geriatric Care, North York, Ontario, Canada. calain@rotman-baycrest.on.ca
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't