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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-11-19
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pubmed:abstractText |
Liver-kidney microsome type 1 (LKM1) antibodies are specific markers of autoimmune hepatitis (AIH) type 2. Antibodies to LKM1 have been found in 2% to 3% of adults infected with hepatitis C virus (HCV) without AIH. Thirty percent of these antibodies are directed against linear sequences of CYP2D6 protein. LKM1 antibodies in HCV+/LKM1+ sera and in sera of AIH patients do not recognize the same CYP2D6 epitopes. The current study was conducted to determine whether LKM1 antibodies in HCV+/LKM1+ children's sera are the result of the same immune response as the antibodies described in AIH type 2 and in HCV+/LKM1+ adult patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0277-2116
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
551-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10554122-Adolescent,
pubmed-meshheading:10554122-Adult,
pubmed-meshheading:10554122-Autoantibodies,
pubmed-meshheading:10554122-Blotting, Western,
pubmed-meshheading:10554122-Child,
pubmed-meshheading:10554122-Child, Preschool,
pubmed-meshheading:10554122-Cytochrome P-450 CYP2D6,
pubmed-meshheading:10554122-Epitopes,
pubmed-meshheading:10554122-Female,
pubmed-meshheading:10554122-Hepatitis, Autoimmune,
pubmed-meshheading:10554122-Hepatitis C, Chronic,
pubmed-meshheading:10554122-Humans,
pubmed-meshheading:10554122-Immunoglobulin G,
pubmed-meshheading:10554122-Immunoglobulin M,
pubmed-meshheading:10554122-Kidney,
pubmed-meshheading:10554122-Male,
pubmed-meshheading:10554122-Microsomes,
pubmed-meshheading:10554122-Microsomes, Liver
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pubmed:year |
1999
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pubmed:articleTitle |
Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera.
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pubmed:affiliation |
Department of Pediatrics, Sainte-Justine Hospital, University of Montréal, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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