Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1999-12-2
pubmed:abstractText
PAX3 and PAX7 are closely related paired box family members expressed during early neural and myogenic development. Assay of PAX3 and PAX7 mRNA expression in embryonal rhabdomyosarcoma, neuroblastoma, Ewing's sarcoma, and melanoma cell lines revealed tumor-specific expression patterns similar to the corresponding embryonic lineages. Although the mammalian PAX3 and PAX7 genes were reported to contain eight exons, we found that the predominant PAX3 and PAX7 transcripts in these tumor lines contain previously uncharacterized ninth exons. These splicing events alter the COOH-terminal coding regions of the encoded products but do not alter the transcriptional activity as assayed using a reporter gene with a model PAX3/PAX7 binding site. However, the findings of nearly identical COOH-terminal regions within the corresponding genes of the avian and fish genomes suggest conserved functional roles for these regions that require further investigation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PAX3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PAX7 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/PAX7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Pax3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pax7 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5443-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10554014-Alternative Splicing, pubmed-meshheading:10554014-Amino Acid Sequence, pubmed-meshheading:10554014-Animals, pubmed-meshheading:10554014-Base Sequence, pubmed-meshheading:10554014-DNA-Binding Proteins, pubmed-meshheading:10554014-Exons, pubmed-meshheading:10554014-Gene Expression Regulation, Neoplastic, pubmed-meshheading:10554014-Homeodomain Proteins, pubmed-meshheading:10554014-Humans, pubmed-meshheading:10554014-Melanoma, pubmed-meshheading:10554014-Mice, pubmed-meshheading:10554014-Models, Genetic, pubmed-meshheading:10554014-Molecular Sequence Data, pubmed-meshheading:10554014-Muscle Proteins, pubmed-meshheading:10554014-Nerve Tissue Proteins, pubmed-meshheading:10554014-Neuroblastoma, pubmed-meshheading:10554014-PAX7 Transcription Factor, pubmed-meshheading:10554014-Paired Box Transcription Factors, pubmed-meshheading:10554014-Plasmids, pubmed-meshheading:10554014-RNA, Messenger, pubmed-meshheading:10554014-Rhabdomyosarcoma, pubmed-meshheading:10554014-Sarcoma, Ewing, pubmed-meshheading:10554014-Sequence Homology, Amino Acid, pubmed-meshheading:10554014-Transcription, Genetic, pubmed-meshheading:10554014-Transcription Factors, pubmed-meshheading:10554014-Tumor Cells, Cultured
pubmed:year
1999
pubmed:articleTitle
Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6082, USA. barrfg@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't