|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1999-11-16
|
|
pubmed:abstractText |
Abnormalities in prefrontal cortical gamma-aminobutyric acid (GABA) neurotransmission may contribute to cognitive dysfunction in schizophrenia. The density of chandelier neuron axon terminals (cartridges) immunoreactive for the GABA membrane transporter (GAT-1) has been reported to be reduced in the dorsolateral prefrontal cortex of schizophrenic subjects. Because cartridges regulate the output of pyramidal cells, this study analyzed the laminar distribution of GAT-1-immunoreactive cartridges to determine whether certain subpopulations of pyramidal cells are preferentially affected.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0002-953X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
156
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1709-19
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10553733-Animals,
pubmed-meshheading:10553733-Antipsychotic Agents,
pubmed-meshheading:10553733-Axons,
pubmed-meshheading:10553733-Carrier Proteins,
pubmed-meshheading:10553733-Female,
pubmed-meshheading:10553733-GABA Plasma Membrane Transport Proteins,
pubmed-meshheading:10553733-Haloperidol,
pubmed-meshheading:10553733-Humans,
pubmed-meshheading:10553733-Immunohistochemistry,
pubmed-meshheading:10553733-Macaca fascicularis,
pubmed-meshheading:10553733-Male,
pubmed-meshheading:10553733-Membrane Proteins,
pubmed-meshheading:10553733-Membrane Transport Proteins,
pubmed-meshheading:10553733-Middle Aged,
pubmed-meshheading:10553733-Nerve Tissue Proteins,
pubmed-meshheading:10553733-Neural Pathways,
pubmed-meshheading:10553733-Neurons,
pubmed-meshheading:10553733-Organic Anion Transporters,
pubmed-meshheading:10553733-Prefrontal Cortex,
pubmed-meshheading:10553733-Presynaptic Terminals,
pubmed-meshheading:10553733-Pyramidal Cells,
pubmed-meshheading:10553733-Schizophrenia,
pubmed-meshheading:10553733-Schizophrenic Psychology,
pubmed-meshheading:10553733-Thalamus
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects.
|
|
pubmed:affiliation |
Department of Psychiatry, University of Pittsburgh, PA 15213, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
