Source:http://linkedlifedata.com/resource/pubmed/id/10553162
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2000-2-7
|
| pubmed:abstractText |
Ewing's tumors (ET) are primary malignancies of bone and soft tissues characterized in at least 96% of cases by specific fusion transcripts originating from recurrent chromosomal translocations. Clinical protocols for high-risk metastatic ETs include high-dose radiation/chemotherapy followed by autologous peripheral blood stem cell (PBSC) reinfusion. We used nested reverse transcriptase polymerase chain reaction (RT-PCR) to search for the presence of ET-specific transcripts in PBSC collections from patients with high-risk ET in order to collect harvests free from neoplastic cells but still sufficient to obtain early stable engraftment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0390-6078
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1012-5
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:10553162-Child,
pubmed-meshheading:10553162-Chromosomes, Human, Pair 11,
pubmed-meshheading:10553162-Chromosomes, Human, Pair 22,
pubmed-meshheading:10553162-Disease-Free Survival,
pubmed-meshheading:10553162-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10553162-Humans,
pubmed-meshheading:10553162-Oncogene Proteins, Fusion,
pubmed-meshheading:10553162-Recombinant Fusion Proteins,
pubmed-meshheading:10553162-Recurrence,
pubmed-meshheading:10553162-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10553162-Risk Factors,
pubmed-meshheading:10553162-Sarcoma, Ewing,
pubmed-meshheading:10553162-Sensitivity and Specificity,
pubmed-meshheading:10553162-Transcription, Genetic,
pubmed-meshheading:10553162-Translocation, Genetic,
pubmed-meshheading:10553162-Transplantation, Autologous
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Detection of EWS chimeric transcripts by nested RT-PCR to allow reinfusion of uncontaminated peripheral blood stem cells in high-risk Ewing's tumor in childhood.
|
| pubmed:affiliation |
Servizio di Citopatologia; Clinica Pediatrica, Università degli Studi di Bologna, Policlinico S. Orsola, Bologna, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|