| pubmed-article:10553053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C1705955 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10553053 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10553053 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10553053 | pubmed:dateCreated | 1999-12-2 | lld:pubmed |
| pubmed-article:10553053 | pubmed:abstractText | Immunoregulation of lymphocytes and macrophages in the peripheral immune system is achieved in part by activation-induced cell death. Members of the TNF receptor family including Fas (CD95) are involved in the regulation of activation-induced cell death. To determine whether activation-induced cell death plays a role in regulation of dendritic cells (DCs), we examined interactions between Ag-presenting murine DCs and Ag-specific Th1 CD4+ T cells. Whereas mature bone marrow- or spleen-derived DCs expressed high levels of Fas, these DCs were relatively insensitive to Fas-mediated killing by the agonist mAb, Jo-2, as well as authentic Fas ligand expressed on the CD4+ T cell line, A.E7. The insensitivity to Fas-mediated apoptosis was not affected by priming with IFN-gamma and/or TNF-alpha or by blocking the DC survival signals TNF-related activation-induced cytokine and CD40L. However, apoptosis could be induced with C2-ceramide, suggesting that signals proximal to the generation of ceramide might mediate resistance to Fas. Analysis of protein expression of several anti-apoptotic mediators revealed that expression of the intracellular inhibitor of apoptosis Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein was significantly higher in Fas-resistant DCs than in Fas-sensitive macrophages, suggesting a possible role for Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein in DC resistance to Fas-mediated apoptosis. Our results demonstrate that murine DCs differ significantly from other APC populations in susceptibility to Fas-mediated apoptosis during cognate presentation of Ag. Because DCs are most notable for initiation of an immune response, resistance to apoptosis may contribute to this function. | lld:pubmed |
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| pubmed-article:10553053 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10553053 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10553053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10553053 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10553053 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10553053 | pubmed:author | pubmed-author:ElkonK BKB | lld:pubmed |
| pubmed-article:10553053 | pubmed:author | pubmed-author:BhardwajNN | lld:pubmed |
| pubmed-article:10553053 | pubmed:author | pubmed-author:SavirAA | lld:pubmed |
| pubmed-article:10553053 | pubmed:author | pubmed-author:AshanyDD | lld:pubmed |
| pubmed-article:10553053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10553053 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10553053 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10553053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10553053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10553053 | pubmed:pagination | 5303-11 | lld:pubmed |
| pubmed-article:10553053 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10553053 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10553053 | pubmed:articleTitle | Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. | lld:pubmed |
| pubmed-article:10553053 | pubmed:affiliation | Hospital for Special Surgery, Cornell University Medical Center, New York 10021, USA. ashanyd@hss.edu | lld:pubmed |
| pubmed-article:10553053 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10553053 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10553053 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14102 | entrezgene:pubmed | pubmed-article:10553053 | lld:entrezgene |
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