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rdf:type |
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lifeskim:mentions |
umls-concept:C0001047,
umls-concept:C0002903,
umls-concept:C0005516,
umls-concept:C0025519,
umls-concept:C0044729,
umls-concept:C0074414,
umls-concept:C0086930,
umls-concept:C0243144,
umls-concept:C0332157,
umls-concept:C0530573,
umls-concept:C1707455
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pubmed:issue |
5
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pubmed:dateCreated |
1999-11-24
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pubmed:abstractText |
Sevoflurane is degraded during low-flow anesthesia to fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A"), which causes renal necrosis in rats but is not known to cause nephrotoxicity in surgical patients. Compound A is metabolized to glutathione S-conjugates and then to cysteine S-conjugates, which are N-acetylated to mercapturic acids (detoxication pathway), or metabolized by renal beta-lyase to reactive intermediates (toxification pathway) and excreted as 3,3,3-trifluoro-2-fluoromethoxypropanoic acid. This investigation quantified compound A metabolites in urine after low-flow sevoflurane administration, to assess relative flux via these two pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,3,3-trifluoro-2-(fluoromethoxy)pro...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocarbons, Fluorinated,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Propionates,
http://linkedlifedata.com/resource/pubmed/chemical/fluoromethyl...,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1267-78
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10551576-Acetylation,
pubmed-meshheading:10551576-Acetylcysteine,
pubmed-meshheading:10551576-Adult,
pubmed-meshheading:10551576-Aged,
pubmed-meshheading:10551576-Anesthesia, Inhalation,
pubmed-meshheading:10551576-Anesthetics, Inhalation,
pubmed-meshheading:10551576-Animals,
pubmed-meshheading:10551576-Cysteine,
pubmed-meshheading:10551576-Ethers,
pubmed-meshheading:10551576-Female,
pubmed-meshheading:10551576-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:10551576-Glutathione,
pubmed-meshheading:10551576-Humans,
pubmed-meshheading:10551576-Hydrocarbons, Fluorinated,
pubmed-meshheading:10551576-Male,
pubmed-meshheading:10551576-Metabolic Detoxication, Drug,
pubmed-meshheading:10551576-Methyl Ethers,
pubmed-meshheading:10551576-Middle Aged,
pubmed-meshheading:10551576-Propionates,
pubmed-meshheading:10551576-Rats,
pubmed-meshheading:10551576-Surgical Procedures, Elective
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pubmed:year |
1999
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pubmed:articleTitle |
Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
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pubmed:affiliation |
Department of Anesthesiology, University of Washington, Seattle 98195, USA. kharasch@u.washington.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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