Linked Life Data

10551555

Source:http://linkedlifedata.com/resource/pubmed/id/10551555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-12-6
pubmed:abstractText
We review the rationale for, and the results of, clinical trials on chemoradiotherapy-based pretransplant regimens for non-Hodgkin's lymphomas, Hodgkin's disease and multiple myeloma. What clearly emerges from this review is the lack of any conclusive evidence that total-body irradiation (TBI)-containing regimens are better than chemotherapy alone in diseases which are considered to be radiosensitive. Due to the variety of pretransplant regimens adopted, the relatively low number of patients enrolled in each trial, and the lack of randomized studies, no one conditioning scheme, with or without TBI, could be identified as superior to another. Only randomized clinical studies will indicate whether TBI-containing regimens are superior to chemotherapy-only regimens and whether TBI and/or involved field radiation therapy have a place in autologous stem cell transplantation programs for lymphoproliferative disorders. And finally, the best TBI dose, schedule, and technique should be defined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1083-7159
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
386-97
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Total-body irradiation in the conditioning regimens for autologous stem cell transplantation in lymphoproliferative diseases.
pubmed:affiliation
U.O. Radiotherapy Oncology, Perugia General Hospital, Italy.
pubmed:publicationType
Journal Article, Meta-Analysis