Linked Life Data

1055101

Source:http://linkedlifedata.com/resource/pubmed/id/1055101

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-7-18
pubmed:abstractText
The cytotoxic effects mediated by lymphocytes from cancer patients after in vitro "education" on autologous tumor cells have been investigated. Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor-cell monolayers and tested thereafter in a micro-cytotoxicity assay against tumor and fibroblast cells. This procedure led to the progeny of non-specific killer cells. As the phenomenon did not occur when the same lymphocytes were co-cultivated with autologous fibroblasts, the generation of non-specific effector cells may have been caused by specific antigenic triggering. The presence of autologous serum during "education" was found to inhibit the manifestation and/or the generation of killer cells. The same serum was without effect when added during the cytotoxicity assay only.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
342-50
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
In vitro "education" on autologous human sarcoma generates non-specific killer cells.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S.