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pubmed-article:10550570pubmed:abstractTextPhosphatidylinositol (PtdIns) 3-kinase is an important mediator of many cellular functions. The study of PtdIns 3-kinase has been facilitated by the existence of the potent irreversible inhibitor of p110 PtdIns 3-kinase, wortmannin. The purpose of the study was to investigate the relationship between the cell growth inhibitory activity and antitumor activity of wortmannin and inhibition of PtdIns 3-kinase.lld:pubmed
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pubmed-article:10550570pubmed:articleTitleWortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase.lld:pubmed
pubmed-article:10550570pubmed:affiliationArizona Cancer Center, University of Arizona, Tucson AZ 85724-5024, USA.lld:pubmed
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