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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-11-30
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pubmed:abstractText |
Phosphatidylinositol (PtdIns) 3-kinase is an important mediator of many cellular functions. The study of PtdIns 3-kinase has been facilitated by the existence of the potent irreversible inhibitor of p110 PtdIns 3-kinase, wortmannin. The purpose of the study was to investigate the relationship between the cell growth inhibitory activity and antitumor activity of wortmannin and inhibition of PtdIns 3-kinase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10550570-Androstadienes,
pubmed-meshheading:10550570-Animals,
pubmed-meshheading:10550570-Breast Neoplasms,
pubmed-meshheading:10550570-Cell Division,
pubmed-meshheading:10550570-Enzyme Inhibitors,
pubmed-meshheading:10550570-Female,
pubmed-meshheading:10550570-Humans,
pubmed-meshheading:10550570-Mammary Neoplasms, Experimental,
pubmed-meshheading:10550570-Mice,
pubmed-meshheading:10550570-Mice, Inbred C3H,
pubmed-meshheading:10550570-Mice, SCID,
pubmed-meshheading:10550570-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:10550570-Transplantation, Heterologous,
pubmed-meshheading:10550570-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase.
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pubmed:affiliation |
Arizona Cancer Center, University of Arizona, Tucson AZ 85724-5024, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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