Linked Life Data

10549800

Source:http://linkedlifedata.com/resource/pubmed/id/10549800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2000-1-4
pubmed:abstractText
Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mechanical stimulation following segmental ligation of spinal nerves in the rat. MK-801, an NMDA receptor antagonist, was microinjected into the rostroventromedial medulla (RVM) 15 min before or 25 min after the ligation of spinal nerves and mechanical hypersensitivity was assessed at various time points following surgery by determining the hindlimb withdrawal threshold to noxious and innocuous mechanical stimulation. A single dose of MK-801 administered prior to nerve ligation into the RVM significantly attenuated the development of mechanical hypersensitivity throughout the 2 week postoperative observation period, whereas corresponding administration of MK-801 immediately after the nerve ligation attenuated the development of mechanical hypersensitivity only during the first postoperative day but not later. The results indicate that NMDA receptors in the RVM are involved in triggering the enhanced sensitivity to mechanical stimulation induced by a nerve injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2933-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
MK-801, an NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat.
pubmed:affiliation
Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't