|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1999-11-23
|
|
pubmed:abstractText |
Targeted immune regulation can be achieved by use of tissue-specific T cells and offers the potential for organ-specific suppression of destructive autoimmune processes. Here, we report the generation and characterization of insulin B chain-specific "autoreactive" CD4+ regulatory T cells that locally suppress diabetogenic T cell responses against an unrelated self-antigen (viral transgene) in a virus-induced model for type 1 diabetes. Interleukin 4 (IL-4) is essential for prevention of diabetes since regulatory T cells cannot be induced in the absence of IL-4 or stat6 (IL-4 signaling pathway). Our observations demonstrate that autoreactive regulatory T cells can suppress autoreactive destructive T cell activity of differential antigenic specificity locally in the pancreatic draining lymph node, probably via cytokine-mediated modulation of antigen-presenting cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
463-72
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:10549628-Administration, Oral,
pubmed-meshheading:10549628-Adoptive Transfer,
pubmed-meshheading:10549628-Animals,
pubmed-meshheading:10549628-Autoimmune Diseases,
pubmed-meshheading:10549628-Autoimmunity,
pubmed-meshheading:10549628-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10549628-Diabetes Mellitus, Type 1,
pubmed-meshheading:10549628-Insulin,
pubmed-meshheading:10549628-Interferon-gamma,
pubmed-meshheading:10549628-Interleukin-10,
pubmed-meshheading:10549628-Interleukin-4,
pubmed-meshheading:10549628-Lymph Nodes,
pubmed-meshheading:10549628-Lymphocytic Choriomeningitis,
pubmed-meshheading:10549628-Lymphocytic choriomeningitis virus,
pubmed-meshheading:10549628-Mice,
pubmed-meshheading:10549628-Mice, Inbred BALB C,
pubmed-meshheading:10549628-Mice, Transgenic,
pubmed-meshheading:10549628-Nucleoproteins,
pubmed-meshheading:10549628-Pancreas,
pubmed-meshheading:10549628-Peptide Fragments,
pubmed-meshheading:10549628-Promoter Regions, Genetic,
pubmed-meshheading:10549628-Recombinant Fusion Proteins,
pubmed-meshheading:10549628-STAT6 Transcription Factor,
pubmed-meshheading:10549628-Swine,
pubmed-meshheading:10549628-T-Lymphocyte Subsets,
pubmed-meshheading:10549628-Trans-Activators,
pubmed-meshheading:10549628-Viral Proteins
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.
|
|
pubmed:affiliation |
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
