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rdf:type |
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lifeskim:mentions |
umls-concept:C0007623,
umls-concept:C0035820,
umls-concept:C0443199,
umls-concept:C0449432,
umls-concept:C0521009,
umls-concept:C0524637,
umls-concept:C1179435,
umls-concept:C1336634,
umls-concept:C1336636,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248
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pubmed:issue |
4
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pubmed:dateCreated |
1999-11-23
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pubmed:abstractText |
Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidoglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Teichoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/lipoteichoic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
443-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10549626-Animals,
pubmed-meshheading:10549626-Antigens, Bacterial,
pubmed-meshheading:10549626-Cell Wall,
pubmed-meshheading:10549626-Corynebacterium diphtheriae,
pubmed-meshheading:10549626-Drosophila Proteins,
pubmed-meshheading:10549626-Escherichia coli,
pubmed-meshheading:10549626-Female,
pubmed-meshheading:10549626-Gram-Negative Bacteria,
pubmed-meshheading:10549626-Gram-Positive Bacteria,
pubmed-meshheading:10549626-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:10549626-Lipid A,
pubmed-meshheading:10549626-Lipopolysaccharides,
pubmed-meshheading:10549626-Macrophages, Peritoneal,
pubmed-meshheading:10549626-Male,
pubmed-meshheading:10549626-Membrane Glycoproteins,
pubmed-meshheading:10549626-Mice,
pubmed-meshheading:10549626-Mice, Inbred C57BL,
pubmed-meshheading:10549626-Mice, Knockout,
pubmed-meshheading:10549626-NF-kappa B,
pubmed-meshheading:10549626-Nocardia,
pubmed-meshheading:10549626-Peptidoglycan,
pubmed-meshheading:10549626-Protein Isoforms,
pubmed-meshheading:10549626-Protein Kinases,
pubmed-meshheading:10549626-Receptors, Cell Surface,
pubmed-meshheading:10549626-Salmonella,
pubmed-meshheading:10549626-Signal Transduction,
pubmed-meshheading:10549626-Species Specificity,
pubmed-meshheading:10549626-Staphylococcus aureus,
pubmed-meshheading:10549626-Teichoic Acids,
pubmed-meshheading:10549626-Toll-Like Receptor 2,
pubmed-meshheading:10549626-Toll-Like Receptor 4,
pubmed-meshheading:10549626-Toll-Like Receptors
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pubmed:year |
1999
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pubmed:articleTitle |
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
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pubmed:affiliation |
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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