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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-11-23
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pubmed:abstractText |
Families of clonally expressed major histocompatibility complex (MHC) class I-specific receptors provide specificity to and regulate the function of natural killer (NK) cells. One of these receptors, mouse Ly49A, is expressed by 20% of NK cells and inhibits the killing of H-2D(d) but not D(b)-expressing target cells. Here, we show that the trans-acting factor TCF-1 binds to two sites in the Ly49A promoter and regulates its activity. Moreover, we find that TCF-1 determines the size of the Ly49A NK cell subset in vivo in a dosage-dependent manner. We propose that clonal Ly49A acquisition during NK cell development is regulated by TCF-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Klra1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T Cell Transcription Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/TCF7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b)
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10549625-Animals,
pubmed-meshheading:10549625-Antigens, Ly,
pubmed-meshheading:10549625-Binding Sites,
pubmed-meshheading:10549625-Burkitt Lymphoma,
pubmed-meshheading:10549625-Cell Line,
pubmed-meshheading:10549625-Cell Lineage,
pubmed-meshheading:10549625-Clone Cells,
pubmed-meshheading:10549625-Cytotoxicity, Immunologic,
pubmed-meshheading:10549625-DNA-Binding Proteins,
pubmed-meshheading:10549625-Dose-Response Relationship, Immunologic,
pubmed-meshheading:10549625-Gene Expression Regulation,
pubmed-meshheading:10549625-Green Fluorescent Proteins,
pubmed-meshheading:10549625-H-2 Antigens,
pubmed-meshheading:10549625-Humans,
pubmed-meshheading:10549625-Jurkat Cells,
pubmed-meshheading:10549625-Killer Cells, Natural,
pubmed-meshheading:10549625-Lectins, C-Type,
pubmed-meshheading:10549625-Luminescent Proteins,
pubmed-meshheading:10549625-Lymphocyte Count,
pubmed-meshheading:10549625-Lymphocyte Subsets,
pubmed-meshheading:10549625-Lymphoid Enhancer-Binding Factor 1,
pubmed-meshheading:10549625-Mice,
pubmed-meshheading:10549625-Mice, Inbred C57BL,
pubmed-meshheading:10549625-Mice, Knockout,
pubmed-meshheading:10549625-NK Cell Lectin-Like Receptor Subfamily A,
pubmed-meshheading:10549625-Promoter Regions, Genetic,
pubmed-meshheading:10549625-Radiation Chimera,
pubmed-meshheading:10549625-Receptors, Immunologic,
pubmed-meshheading:10549625-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:10549625-Recombinant Fusion Proteins,
pubmed-meshheading:10549625-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:10549625-Self Tolerance,
pubmed-meshheading:10549625-T Cell Transcription Factor 1,
pubmed-meshheading:10549625-Thymoma,
pubmed-meshheading:10549625-Thymus Neoplasms,
pubmed-meshheading:10549625-Transcription, Genetic,
pubmed-meshheading:10549625-Transcription Factors,
pubmed-meshheading:10549625-Transfection,
pubmed-meshheading:10549625-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
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pubmed:affiliation |
Ludwig Institute for Cancer Research Lausanne Branch, University of Lausanne, Epalinges, Switzerland. wheld@isrec.unil.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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