| pubmed-article:10549622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:10549622 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:10549622 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10549622 | pubmed:dateCreated | 1999-11-23 | lld:pubmed |
| pubmed-article:10549622 | pubmed:abstractText | Naive Itk-deficient CD4+ T cells were unable to establish stable IL-4 production, even when primed in Th2-inducing conditions. In contrast, IFNgamma production was little affected. Failure to express IL-4 occurred even among cells that had gone through multiple cell divisions and was associated with a delay in the kinetics and magnitude of NFATc nuclear localization. IL-4 production was restored genetically by retroviral reconstitution of Itk or biochemically by augmenting the calcium flux with ionomycin. In vivo, Itk-deficient mice were unable to establish functional Th2 cells. Development of protective Th1 cells was unimpeded. These data define a nonredundant role for Itk in modulating signals from the TCR/CD28 pathways that are specific for the establishment of stable IL-4 but not IFNgamma expression. | lld:pubmed |
| pubmed-article:10549622 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10549622 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10549622 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10549622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10549622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10549622 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10549622 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:CoffmanR LRL | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:ShinkaiKK | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:LittmanD RDR | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:BeebeA MAM | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:LocksleyR MRM | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:LiaoX CXC | lld:pubmed |
| pubmed-article:10549622 | pubmed:author | pubmed-author:FowellD JDJ | lld:pubmed |
| pubmed-article:10549622 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10549622 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10549622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10549622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10549622 | pubmed:pagination | 399-409 | lld:pubmed |
| pubmed-article:10549622 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10549622 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10549622 | pubmed:articleTitle | Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. | lld:pubmed |
| pubmed-article:10549622 | pubmed:affiliation | Department of Medicine, University of California San Francisco 94143, USA. | lld:pubmed |
| pubmed-article:10549622 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10549622 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10549622 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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